THE EFFECT OF X-IRRADIATION AND GLUCOSE ON BRAIN LIPID SYNTHESIS

Journal Article · Wed Dec 31 23:00:00 EST 1958 · Arch. intern. physiol. et biochem.

OSTI ID:4181469

Grossi, E; Paoletti, P; Paoletti, R

Rat x irradiation induces an increase in the rate of cholesterol and fatty acid biosynthesis from 1-C/sup 14/ acetate, but has an iralbitory effect on brain lipid biosynthesis. Cholesterol and fatty acid biosynthesis from 2-C/sup 14/ mevaloric acid is slightiy increased by x irradiation in the liver, but is unchanged in the brain. Glucose added to the incubation medium increases the rate of lipid synthesis in the brain, to a greater extent than in the liver and has a marked effect on mevaloric acid incorporation into brain lipids. The effect of x irradiation is not modified by increasing the levels of liver and brain glucose. (auth)

• Research Organization: Univ. of Milan
• NSA Number: NSA-14-008357
• OSTI ID: 4181469
• Journal Information: Arch. intern. physiol. et biochem., Journal Name: Arch. intern. physiol. et biochem. Vol. Vol: 67
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ACETATES
BIOCHEMISTRY
BIOLOGY AND MEDICINE
BRAIN
CARBON 14
CHOLESTEROL
GLUCOSE
LABELLED COMPOUNDS
LIPIDS
LIVER
MEVALONIC ACID
ORGANIC ACIDS
QUANTITY RATIO
RADIATION EFFECTS
RATS
SUGARS
X RADIATION