PROSPECTIVE POTENTIALITIES OF LYMPHOID TISSUE TO INDUCE HAEMATOPOIETIC RECOVERY IN IRRADIATED MICE PROTECTED BY HYPOXIA
Journal Article
·
· Folia Biologica (Prague) (Czechoslovakia)
OSTI ID:4180060
A qualitative and quantitative evaluation of the protective effect of hypoxia on the spleen of mice irradiated with a dose of 650 r and 750 r was carried out In protected animals destruction of the spleen lumpha, nodules was significantly less than in unprotected mice. Within four days after irradiation, new light centers were formed. while in unprotected mice the nodules underwent further regression. In protected mice a statistically significantly higher level of lymphocytes was maintained in the peripheral blood for 24 hours to four days after irradiation. The granulocyte level war the same as in unprotected animals. Differentiation of reticular cells into blast cells was accompanied in protected animals by smaller degenerative changes in the nucleus and by greater capacity for further maturation in the granulocyte series. In protected animals dedifferentiation of basis into reticular syncytium took place to a smaller degree. The findings are discussed in agreement with the assumption that regeneration of the hematopoietic tissue of protected animals depends on smaller damage to the lymphocytes. nucleic acid fragments from which are utilized in the differentiation of reticular cells into blasts. (auth)
- Research Organization:
- Inst. of Biophysics, Czechoslovak Academy of Sciences, Brno; Comenius Univ., Kosice, Czech.
- NSA Number:
- NSA-14-021316
- OSTI ID:
- 4180060
- Journal Information:
- Folia Biologica (Prague) (Czechoslovakia), Journal Name: Folia Biologica (Prague) (Czechoslovakia) Vol. Vol: 6; ISSN FOBLA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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