SOME DATA ON THE MECHANISM OF RADIATION AFFECTION OF HEMATOPOIESIS (in Russian)
The mechanism of radiation affection of the blood system in radiation sickness was investigated using a lead screen for protection of a portion of hematopoietic tissue at the time of whole-body x-ray irradiation. Experiments were staged on 208 white rats divided into three groups. The dose of irradiation was 500 r. A portion of the bone marrow was screened in the animals of the first and second group. The control rats were subject to irradiation without any protection. In the animals of the third group, the spleen was mobilized through an incisure in the abdonfinal wall and protected. The control rats of this group were subject to an abdominal wall incisure before the irradiation. All animals of the third group underwent irradiation under ether anesthesia. The peripheral blood and hematopoietic organs were investigated before the experiment and on the lst, 3rd, 5th, l0th, l2th, and 20th day after the irradiation. The results show that protection of a portion of bone marrow or spleen was inducive to a larger survival rate of the experimental animals and effected a more rapid and complete regeneration of the blood. Screening was found to dinunish the primary affection of the protected portion of hematopoietic tissue. Certain pathological processes characteristic for radiation injury developed at a later time. The principal link in radiation affection of hematopoiesis was found to be the disturbed ability of polypotent reticular cells of hematopoietic organs to differentiate and pass into the blood cells. Protective screening produced a retention of early stages of hematopoiesis (absence of inhibition during the passing of reticular cells into the blood cells). (auth)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-14-012475
- OSTI ID:
- 4170953
- Journal Information:
- Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR, Journal Name: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR Vol. Vol: 5, No. 2; ISSN MERAA
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
Similar Records
BENEFICIAL EFFECT OF THE SHIELDING OF NONHOMOPOIETIC ORGANS ON THE RESTORATION OF HEMATOPOIESIS IN IRRADIATED MICE
STUDY ON COBALT-GREENPOLE. III. THE EFFECT OF COBALT-GREENPOLE ON TISSUE RESPIRATION