THE SPECIFIC FEATURES OF HEMATOPOIESIS IN RATS AND THEIR OFFSPRING IN THE ACTION OF Sr$sup 9$$sup 0$

Journal Article · Mon Feb 01 04:00:00 EST 1960 · Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR

OSTI ID:4194383

Ivanova, T A

The introduction of Sr/sup 90/ (0.4 mC/gm) to female rats before pregancy was found to provoke a number of changes in the peripheral blood and hematopoietic organs not only in the rats but also in their offspring. On the 1st to 3rd day following Sr/sup 90/ administration, an increase in the number of blood cells was observed in rats, due to mature cells from the bone marrow. The subsequent drop in the number of cells (3rd to 30th day) depended upon the disturbance of hematopoiesis, which was manifested by a retarded transition of reticular cells into blood cells and an inhibition of their maturation. Between the 2nd and 6th month a rise of the blond cell count was observed which was associated, apparently, with the restoration of the processes of differentiation and cell maturation in the hematopoietic organs. At later stages (7th to 11th month) a marked leukocytosis in the peripheral blood was observed, the latter being due to hyperplasia of the leukoblastic portion of the bone marrow. In the offspring of the irradiated female rats, pronounced fluctuations in the blood cell count of the peripheral blood were observed at the age of 1 to 3 months. The changes found in rats at a more advanced age (3 to 9 months) were characterized by marked leukocytosis of neutrophil nature and the appearance of plasmatic and reticular cells, associated with an increase of the leukoblastic portion in the bone marrow and a disturbance of processes of cell development and maturation. (auth)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-14-012510
• OSTI ID: 4194383
• Journal Information: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR, Journal Name: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR Vol. Vol: 5, No. 2; ISSN MERAA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

AGE
BIOLOGY AND MEDICINE
BLOOD CELLS
BLOOD CIRCULATION
BLOOD FORMATION
BONE MARROW
CYTOLOGY
IRRADIATION
LEUCOCYTES
LEUKEMIA
NEUTROPHILS
PREGNANCY
RADIATION INJURIES
RADIATION SICKNESS
RATS
REGENERATION
REPRODUCTION
SEX
STRONTIUM 90
TISSUES
VARIATIONS