THE EFFECT OF 2-AMINOETHYLISOTHIOURONIUM /center dot/ Br /center dot/ HBr (AET) ON THYROID ACTIVITY IN NONIRRADIATED AND X-IRRADIATED RATS

Journal Article · Mon Aug 01 04:00:00 EDT 1960 · Radiation Research

DOI:https://doi.org/10.2307/3570958· OSTI ID:4174213

Vittorio, P V; Allen, M J

In the control groups of rats, whole-bcdy x irradiation increased I/sup 131/ uptake by the thyroids and by the proteinbound iodine. In AET-injected groups, whole-bcdy x ir radiation decreased I/sup 131/ uptake by the thyroids and by the protein-bound iodine and increased serum I/sup 131/. In both nonirradiated and x irradiated rats AET (200 mg/kg of rat body weight) decreased I/sup 131/ uptake by the thyroids and by protein-bound iodine but increased the serum I/sup 131/ value. This indicates that the increased serum I/sup 131/ value is not due to an increased PBI/sup 131/ value but probably to the inorganic I/sup 131/ which is being picked up by the blood and is not entering the thyroids. If the lowered iodine uptake by the thyroids and by the serum proteins results in a lowered basal metabolic rate, this could help complement other radiopretective actions by AET. (auth)

• Research Organization: Defence Research Lab., Kingston, Ont.
• Sponsoring Organization: USDOE
• NSA Number: NSA-14-021334
• OSTI ID: 4174213
• Journal Information: Radiation Research, Journal Name: Radiation Research Vol. Vol: 13
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AET
BIOLOGY AND MEDICINE
BLOOD SERUM
BODY
IODINE 131
METABOLISM
ORGANIC SULFUR COMPOUNDS
PROTEINS
QUANTITY RATIO
RADIATION EFFECTS
RADIATION PROTECTION
RATS
THYROID
X RADIATION