Comparative Effects of I131 and X-Irradiation on Sheep Thyroids
Journal Article
·
· Health Physics
A preliminary study to determine the early comparative effects of I131 and x irradiation on the thyroid was performed in young adult sheep. The thyroid region of one group of animals was exposed to x irradiation, with doses of 750--4500 r given as single or three exposures at weekly intervals. Other animals were given single oral doses of 1.25--5.0 mC I131 with estimated average thyroid radiation doses of 24000-- 90000 rad. Only minimal changes in thyroid function were observed, as evaluated by radioiodine uptake and determination of serum protein-bound iodine. Histopathological changes including inflammation, necrosis, and fibrosis of the thyroid were observed in the exposed animals and were generally dose dependent. In the x irradiated animals, tissue damage was observed in the structures contiguous to the thyroid gland.
- Research Organization:
- General Electric Co., Richland, Wash.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-18-008162
- OSTI ID:
- 4113360
- Report Number(s):
- HW-SA-3076; 0017-9078
- Journal Information:
- Health Physics, Journal Name: Health Physics Journal Issue: 12 Vol. 9; ISSN 0017-9078
- Publisher:
- Health Physics Society
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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