Comparative Effects of I131 and X-Irradiation on Sheep Thyroids

Journal Article · Tue Jan 01 04:00:00 EST 1963 · Health Physics

DOI:https://doi.org/10.1097/00004032-196312000-00045· OSTI ID:4113360

McClellan, R. O.; Clarke, W. J.; Ragan, H. A.; Wood, D. H.; Bustad, L. K.

A preliminary study to determine the early comparative effects of I¹³¹ and x irradiation on the thyroid was performed in young adult sheep. The thyroid region of one group of animals was exposed to x irradiation, with doses of 750--4500 r given as single or three exposures at weekly intervals. Other animals were given single oral doses of 1.25--5.0 mC I¹³¹ with estimated average thyroid radiation doses of 24000-- 90000 rad. Only minimal changes in thyroid function were observed, as evaluated by radioiodine uptake and determination of serum protein-bound iodine. Histopathological changes including inflammation, necrosis, and fibrosis of the thyroid were observed in the exposed animals and were generally dose dependent. In the x irradiated animals, tissue damage was observed in the structures contiguous to the thyroid gland.

• Research Organization: General Electric Co., Richland, Wash.
• Sponsoring Organization: USDOE
• NSA Number: NSA-18-008162
• OSTI ID: 4113360
• Report Number(s): HW-SA-3076; 0017-9078
• Journal Information: Health Physics, Journal Name: Health Physics Journal Issue: 12 Vol. 9; ISSN 0017-9078
• Publisher: Health Physics Society
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
AGE
ANIMALS
BLOOD SERUM
CYTOLOGY
DISTRIBUTION
FIBROSIS
INTESTINE
IODINE 131
IODINE COMPOUNDS
METABOLISM
NECROSIS
ORGANIC IODINE COMPOUNDS
PHYSIOLOGY
PROTEINS
QUANTITATIVE ANALYSIS
RADIATION DOSES
RADIATION EFFECTS
SHEEP
THYROID
TISSUES
VARIATIONS
X RADIATION