THYROID ADENOMAS IN SHEEP FED RADIOIODINE
The development of thyroid adenomas at an age of four to eight years is reported for ten sheep fed daily quantities of I/sup 131/ ranging from 1.5 to 135 mu c. Combining these results with the occurrence of adenomas previously reported in four sheep and a fibrosarcoma in a fifth gives an incidence of 15 animals bearing thyroid neoplasms out of 18 treated with the stated quantities. The exposure to I/sup 131/ was either continuous from conception or initiated at an age of 15 months. The radiation doses to the thyroid glands were estimated to range from 7,000 to over 100,000 rads for the affected animals. Thyroid adenomas in control sheep were limited to animals ten years of age or older but were identical in appearance to those of the experimental animals. The histologic characteristics of the adenomas are described. The mechanism of stimulation of the thyroid gland by an excessive output of thyroid stimulating hormone was invoked to explain the abnormal incidence of adenomas in the sheep fed I/sup 131/. (auth)
- Research Organization:
- General Electric Co. Hanford Atomic Products Operation, Richland, Wash.
- DOE Contract Number:
- AT(45-1)-1350
- NSA Number:
- NSA-17-005768
- OSTI ID:
- 4739658
- Report Number(s):
- HW-SA-2493
- Country of Publication:
- United States
- Language:
- English
Similar Records
RADIOIODINE-INDUCED THYROID CARCINOMAS IN FEMALE RATS INDUCTION BY LOW DOSES OF RADIOIODINE
INDUCTION OF NEOPLASMS IN THYROID GLANDS OF RATS BY SUBTOTAL THYROIDECTOMY AND BY THE INJECTION OF ONE MICROCURIE OF I$sup 13$$sup 1$