Radiation dose to the human body from intravenously administered $sup 75$Se- sodium selenite
Journal Article
·
· J. Nucl. Med., v. 16, no. 9, pp. 846-850
OSTI ID:4173223
The dose of radiation to the human body and some of its organs after intravenous administration of $sup 75$Se-sodium selenite for diagnostic purposes was calculated on the basis of followup of 26 patients, for as long as 517 days with measurements of: the retention of $sup 75$Se in the whole body; the retention of f $sup 75$Se in the blood, liver, kidneys, ovaries, testicles, and hair, and the excretion of $sup 75$Se in urine and feces. Whole-body counting and profile scanning were done on the patients, and samples of blood from different organs, urine, and feces were measured for radioactivity. The dose of radiation received was calculated for an average patient of 70 kg. These doses were found to be slightly higher than previously reported on a smaller number of patients and with a shorter followup. They were slightly lower than those from $sup 75$Se-methionine to the whole body but higher to the liver and kidneys. The margin of error in this investigation was estimated to be about 20 percent for the whole-body dose and probably higher for different organs, mostly due to the poorly known rate of retention of selenite in different organs. (auth)
- Research Organization:
- Karolinska Hospital, Stockholm
- NSA Number:
- NSA-33-000987
- OSTI ID:
- 4173223
- Journal Information:
- J. Nucl. Med., v. 16, no. 9, pp. 846-850, Journal Name: J. Nucl. Med., v. 16, no. 9, pp. 846-850; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
*PATIENTS-- RADIATION DOSES
*SELENIUM 75-- RADIONUCLIDE ADMINISTRATION
560161* --Biomedical Sciences
Applied Studies--Radiation Effects--Radionuclide Effects--Internal Source--Man
BLOOD
FECES
INTRAVENOUS INJECTION
MEASURING METHODS
N48610* --Life Sciences--Radionuclide Effects (Internal Source)--Man
N48830 --Life Sciences--New Tracer Techniques--Other
NUCLEAR MEDICINE
RADIOISOTOPE SCANNING
RADIOMETRIC ANALYSIS
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
SAMPLING
SELENITES
SODIUM COMPOUNDS
URINE
WHOLE-BODY COUNTING
*SELENIUM 75-- RADIONUCLIDE ADMINISTRATION
560161* --Biomedical Sciences
Applied Studies--Radiation Effects--Radionuclide Effects--Internal Source--Man
BLOOD
FECES
INTRAVENOUS INJECTION
MEASURING METHODS
N48610* --Life Sciences--Radionuclide Effects (Internal Source)--Man
N48830 --Life Sciences--New Tracer Techniques--Other
NUCLEAR MEDICINE
RADIOISOTOPE SCANNING
RADIOMETRIC ANALYSIS
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
SAMPLING
SELENITES
SODIUM COMPOUNDS
URINE
WHOLE-BODY COUNTING