Retention, organ distribution, and excretory pattern of cadmium orally administered in a single dose to two monkeys
Journal Article
·
· J. Toxicol. Environ. Health; (United States)
- Univ. of Tokyo, Japan
Retention, excretion, and organ distribution of radioactive Cd were observed after a single oral dose of two monkeys. The retention rate of Cd 19 d after the administration of radiocadmium (/sup 109/CdCl/sub 2/, carrier-free) to one monkey was 5.2% of the administered dose; 73.4% of the dose was excreted in the feces and 0.7% in the urine. The largest fractions of the administered dose were found in the small intestine, liver, and kidney. The absorption rate of Cd 25 d after the administration of radiocadmium with 1.0 mg cold Cd as CdCl/sub 2/ solution to the other monkey was 6.3% of the administered dose; 75.5% of the dose was excreted in the feces and 0.9% in the urine. Setting the whole body retention equal to 100% on d 19 or 25, the largest fractions were found in the small intestines (51.5 and 36.3%), livers (21.8 and 29.6%), and kidneys (13.4 and 21.0%) of the respective monkeys). The effect of carrier Cd on absorption, excretion, and organ distribution was not pronounced. The highest concentration and greatest retention of Cd was observed in the upper small intestinal wall and the content of the small intestine, indicating the importance of enteroenteric circulation of the element; this finding was different from the results for Cd metabolism in rodents.
- OSTI ID:
- 5219899
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 6:4; ISSN JTEHD
- Country of Publication:
- United States
- Language:
- English
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560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
CADMIUM
CADMIUM 109
CADMIUM ISOTOPES
DATA
DATA COMPILATION
DATA FORMS
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METABOLISM
METALS
MONKEYS
NUCLEI
NUMERICAL DATA
PRIMATES
RADIOISOTOPES
RODENTS
TABLES
TRACER TECHNIQUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
CADMIUM
CADMIUM 109
CADMIUM ISOTOPES
DATA
DATA COMPILATION
DATA FORMS
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METABOLISM
METALS
MONKEYS
NUCLEI
NUMERICAL DATA
PRIMATES
RADIOISOTOPES
RODENTS
TABLES
TRACER TECHNIQUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES