SUSTAINED ACTION OF INJECTED CHELATING AGENTS
Low-pressure ultrafiltration techniques were used to study the unusual effects of ethylenediaminetetraacetic (EDTA) and diethylenetriaminepentaacetic (DTPA) acids on the elimination of radioactive metals from animals. The Ca salt of DTPA was injected into rats 3 days after an injection of Pu/sup 239/, and the ultrafilterability of Pu from the bone, liver, and plasma was measured after killing the rats at intervals of 1, 2, 3, and 7 days after injection. The results show that the diffusibility of Pu remains > 10x greater than that of control animals for at least 7 days. DTPA was compared with EDTA by addition to blood samples taken from rats 15 min after Pu injection; at chelate concentrations of 10/sup -6/ to 10/sup -5/ M, DTPA was found to be more effective in increasing the % ultrafiltered Pu. The ultrafiltration of Sr in blood was also studied and found to be identical with that of controls up to 2 x 10/sup -2/ M EDTA, a concentration unattainable in the blood of living animals. Experiments similar to those with Pu were made with Th/sup 234/ and gave similar results, DTPA again being superior to EDTA. (D.L.C.)
- Research Organization:
- Argonne National Lab., Ill.
- NSA Number:
- NSA-14-021222
- OSTI ID:
- 4166093
- Journal Information:
- Nature, Journal Name: Nature Vol. Vol: 187
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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