Removal of Internally Deposited Americium by Chelating Agents

Journal Article · Sat Aug 13 00:00:00 EDT 1960 · Nature (London)

DOI:https://doi.org/10.1038/187612a0· OSTI ID:4177264

SOWBY, F. D.; TAYLOR, D. M.

The removal of Am/sup 241/ from rats was studied using ethylenediaminetetraacetic (EDTA) and diethylenetriamanepentaacetic (DTPA) acids. Am/sup 241/ was injected into rats and DTPA injected at times varying from 1 hr to 7 days after Am/sup 241/ injection and repeated at weekly intervals. The rats were killed 21 days after Am/sup 241/ injection and the alpha activities of the liver, femur, carcass, and excreta were counted. A comparison of the results with untreated animals shows that most of Am/sup 241/ is excreted and that practically no Am/sup 241/ is left in the soft tissue. DTPA was found to be about twice as effective as EDTA. (D.L.C.)

• Research Organization: Royal Cancer Hospital, London
• Sponsoring Organization: USDOE
• NSA Number: NSA-14-021588
• OSTI ID: 4177264
• Journal Information: Nature (London), Journal Name: Nature (London) Journal Issue: 4737 Vol. 187; ISSN 0028-0836
• Publisher: Nature Publishing Group
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ALPHA PARTICLES
AMERICIUM 241
BODY
BONES
CHELATES
CHEMISTRY
COUNTERS
DEPOSITS
EDTA
INJECTION
LIVER
RATS
TISSUES
URINE