Plutonium decorporation by mixed ligand chelates. Final report, June 2, 1976--April 15, 1977. [/sup 239/Pu and /sup 234/Th]
The effects of mixed ligand chelates on the removal of /sup 239/Pu and /sup 234/Th from the tissues of mice were investigated. The primary ligands, L/sub 1/, used were mainly EDTA and DTPA, while the secondary ligands, L/sub 2/, were of the bidentate type, as, for example, catechol, salicylic acid, and benzohydroxamic acid. A suitably chosen mixed ligand system binds Pu or Th at physiological pH's about 10/sup 11/ to 10/sup 15/ times greater than EDTA or DTPA. An ultrafiltration screening procedure was employed in which soluble Pu or Th salts were injected into mice, the livers were removed several days later and homogenized in the presence of different concentrations of the single and mixed chelants. Similarly, in vivo studies were carried out in which mice were treated 4 hours post Pu (monomeric) injection (I.P.) with a single injection (I.P.) of the chelant systems. Results to date show that the mixed chelant systems are roughly 10 times more effective than EDTA or DTPA alone. Thus, under conditions where DTPA alone (5 x 10/sup -5/ M) removed 1.1 percent of Pu or Th, DTPA + equimolar catechol removed 13.5 percent and 15 percent respectively. Catechol alone had no significant effect. In an in vivo decorporation experiment, a single injection of DTPA plus catechol reduced the liver burden from 45 percent to 2.3 percent and the skeleton from 22 percent to 5.5 percent.
- Research Organization:
- Pittsburgh Univ., PA (USA)
- OSTI ID:
- 7306684
- Report Number(s):
- COO-2969-1
- Country of Publication:
- United States
- Language:
- English
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Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
AMINES
AMINO ACIDS
ANIMALS
AROMATICS
BENZOHYDROXAMIC ACID
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY BURDEN
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DEVELOPERS
DISTRIBUTION
DRUGS
DTPA
EDTA
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
EXCRETION
HEAVY NUCLEI
HYDROXAMIC ACIDS
HYDROXY ACIDS
HYDROXY COMPOUNDS
IN VITRO
IN VIVO
ISOTOPES
MAMMALS
MICE
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PHARMACOLOGY
PHENOLS
PLUTONIUM 239
PLUTONIUM ISOTOPES
POLYPHENOLS
PYROCATECHOL
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPONSE MODIFYING FACTORS
RODENTS
SALICYLIC ACID
SYNERGISM
TESTING
THORIUM 234
THORIUM ISOTOPES
TISSUE DISTRIBUTION
VERTEBRATES
YEARS LIVING RADIOISOTOPES