SUPERIOR CHELATING AGENTS FOR THE TREATMENT OF PLUTONIUM POISONING
A comparison is made of the relative effectiveness of chelating agents for the removal of plutonium from rats. As a standard of comparison, ethylenediaminetetraacetic acid (EDTA) was used to gage the value of two other chelating agents, diethylenetriaminepentaacetic acid (DTPA), and 2:2'- bisSTAdi(carboxymethyl)amino!diethyl ether (BAETA). Six days after the intravenous injection of a mixture of Pu/sup 239/ and Sr/sup 85/ to rats, intermittent treatment with intraperitoneal injections of equimolar amounts of the three chelating agents was begun. The results show that DTPA and BAETA are several times more effective than EDTA in the removal of Pu, even when treatment is delayed. No effect on Sr/sup 85/ removal was observed for any of the chelating agents, a fact which had been anticipated from their preferential binding for Ca relative to Sr. (auth)
- Research Organization:
- Argonne National Lab., Lemont, Ill.
- NSA Number:
- NSA-13-008556
- OSTI ID:
- 4294658
- Journal Information:
- Atompraxis (West Germany) Incorporated in Kerntechnik, Vol. Vol: 5; Other Information: Orig. Receipt Date: 31-DEC-59
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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