RADIOCHEMICAL DEGRADATION OF CYSTAMINE AND DERIVATIVES (in Italian)
Solutions of cystamine, cysteamine, cystamine disulfoxide, hypotaurine, cysteaminesulfonate, thiotaurine, and taurine, were irradiated with increasing doses of x rays. The extent of the degradation of the above compounds was followed by paper chromatography. The oxidation of cysteamine to cystamine was determined by titration of the thiol groups of the irradiated solution. It was observed that the compounds are degraded to a various extent and it was impossible to correlate the extent of degradation with the followed by paper chromatography. The oxidation of cysteamine to cystamine was determined by titration of the thiol groups of the irradiated solution. It was observed that the compounds are degraded to a various extent and it was impossible to correlate the extent of degradation with the protecting power of the same compounds as found in the literature. The results are consistent with the opinion of a secondary role of the plain scavenging effect in the radioprotection by cystamine. The oxidation of cysteamine to cystamine on the contrary prcceeds to such an extent to be of value in the protection as a scavenger. Nevertheless this, reaction may have a radiobiological importance only if a selective absorption and accumulation of cysteamine in the body compared with other thiols is taken into consideration. (auth)
- Research Organization:
- Universita, Modena, Italy; and Universita, Rome
- NSA Number:
- NSA-15-001212
- OSTI ID:
- 4162680
- Journal Information:
- Ricerca sci., Journal Name: Ricerca sci. Vol. Vol: 30
- Country of Publication:
- Country unknown/Code not available
- Language:
- Italian
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