Fate of four $sup 75$Se-labeled amino acids: studies of some unsuccessful pancreas-scanning agents

Journal Article · Wed Oct 01 04:00:00 EDT 1975 · J. Nucl. Med., v. 16, no. 10, pp. 933-937

OSTI ID:4162178

Tothill, P; Heading, R C

A number of alpha-amino acids labeled with $sup 75$Se were developed in the hope of finding a pancreas-scanning agent superior to L-selenomethionine. Six were submitted for clinical trial and four were tested: D-selenomethionine and three derivatives of selenocysteine. Dynamic scintillation camera studies showed that liver uptake was substantial in all cases but that the time course of accumulation and removal differed between agents. Plasma radioactivity curves demonstrated differences in initial removal rates. Two of the agents showed evidence of incorporation of activity into protein and release into the circulation just as with L-selenomethionine. Whole-body counter measurements showed that the retention of activity from the agents exhibiting early plasma protein incorporation was similar to that of L-selenomethionine. Much of the activity from the other two agents was excreted faster but a small proportion was retained for a long time. Although the cumulated activity and absorbed dose were substantially less for at least two of the agents than for $sup 75$Se-L- selenomethionine, the lack of sufficient pancreatic concentration renders them inferior as scanning agents. (auth)

• Research Organization: Royal Infirmary, Edinburgh
• NSA Number: NSA-33-001050
• OSTI ID: 4162178
• Journal Information: J. Nucl. Med., v. 16, no. 10, pp. 933-937, Journal Name: J. Nucl. Med., v. 16, no. 10, pp. 933-937; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

*PANCREAS-- SCINTISCANNING
*RADIOPHARMACEUTICALS-- TESTING
*SELENIUM 75-- DIAGNOSTIC TECHNIQUES
550601* --Biomedical Sciences
Basic Studies--Medicine-- Unsealed Radionuclides in Diagnostics
AMINO ACIDS
LABELLED COMPOUNDS
N48710 --Life Sciences--Nuclide Kinetics & Toxicology--Man
N48830* --Life Sciences--New Tracer Techniques--Other
NUCLEAR MEDICINE
PATIENTS
RADIONUCLIDE ADMINISTRATION
RADIONUCLIDE KINETICS
TISSUE DISTRIBUTION