ANTIBODY FORMATION IN X-IRRADIATED RATS PROTECTED WITH /cap beta/- MERCAPTOETHYLAMINE AND /cap beta/-AMINOETHYLISOTHIOURONIUM
The investigation of antibody formation was carried out using the sensitive and quantitative technique of titrating hemolysin in 50% hemolytic units and methods of obtaining antibody curves for each rat. Rats irradiated with 550 r total-body x irradiation and immunized 24 hours later with a 0.25% suspension of sheep red cells showed a marked suppression of hemolysin formation. Comparison of log peak titer, induction period and antibody rise to peak and rate of formation gave highly significant differences as compared with nonirradiated control group. Cysteamine given before the exposure to x irradiation protected significantly the induction period, but allowed only about 7% of the expected antibody to be formed at a slightly protected rate of formation within a prolonged antibody rise to peak. AET given before the x irradiation protected only the induction period. Other measures of the antibody response were practically the same as in irradiated controls. Cysteamine or AET given 24 hours before the immunization had no effect on hemolysin formation in nonirradiated rats. (auth)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-14-014685
- OSTI ID:
- 4158985
- Journal Information:
- Bull. Inst. Nuclear Sci. "Boris Kidrich" (Belgrade), Journal Name: Bull. Inst. Nuclear Sci. "Boris Kidrich" (Belgrade) Vol. Vol: 10
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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