HEMOLYSIN FORMATION IN INTACT, SPLENECTOMIZED AND X-IRRADIATED RATS
>Hemolysin formation was studied in intact, splenectomized, x-irradiated as well as in splenectomized and x-irradiated rats immunized with sheep red cells. Following a single intravenous injection of antigen, hemolysins reached in intact rats high titers at a rapid rate of accumulation after a short induction and rise to peak period. Splenectomy performed 3 days or 4 to 6 weeks before the body response (splenectomized rats formed only 1.4% of the amount of antibody formed by intacts). Total-body x irradiation with 480 r produced a significant suppression of the amount of antibody, a lengthening of the induction and rise to peak time, and a slowing of the rate of antibody formation. Splenectomy followed by x irradiation almost completely inhibited the hemolysin formation. These results show that the spleen in the rats is the most important site of hemolysin formation after a single intravenous injection of a small amount of antigen. In x-irradiated rats the spleen remains the most important site of hemolysin formation. (auth)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-14-014686
- OSTI ID:
- 4158952
- Journal Information:
- Bull. Inst. Nuclear Sci. "Boris Kidrich" (Belgrade), Journal Name: Bull. Inst. Nuclear Sci. "Boris Kidrich" (Belgrade) Vol. Vol: 10
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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