THE HEMOLYSIN RESPONSE IN RABBITS IMMUNIZED DURING LOW-LEVEL COBALT-60 GAMMA IRRADIATION
Eleven groups of rabbits were gamma irradiated at the rate of 11 r during 16 consecutive hours out of every 24 hr until they received from 77 to 16l7 r during the course of 7 to 147 days. They were then injected with sheep red-bloodcell stromata and were kept under the same schedule of irradiation for 5 more weeks (385 r) while the hemolysin responses were studied. The hemolysin responses in these irradiated groups did not differ from those of the nonirradiated control group with respect to the mean length of the induction period, the mean rate of the first and most rapid rise of antibody, and the mean log peak titer; but, with increasing irradintion dose. peak titer tended to be reached later at a decreasing average rate. This shift was probably caused by a relative depression of early splenic hemolysin formation and by an increased and later production of hemolysin in one or more nonsplenic sites. (auth)
- Research Organization:
- Argonne National Lab., Ill.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-000074
- OSTI ID:
- 4134342
- Journal Information:
- J. Infectious Diseases, Journal Name: J. Infectious Diseases Vol. Vol: 107
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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