THE RESTORATION OF HEMOLYSIN FORMATION IN X-RAYED RABBITS BY NUCLEIC ACID DERIVATIVES AND ANTAGONISTS OF NUCLEIC ACID SYNTHESIS
The restoration of hemolysin activity was tested in rabbits 24 hr after the administration of 4OO r hard x rays at the approximate low point in their hemolysin-producing capacity. The materials tested were injected intravenously either mixed with the antigen or injected separately at the same time except for colchicine and croton oil. The last two materials were given subcutaneously immediately after injecting the antigen intravenously. Among the chemically defined substances tested, colchicine completely restored and 3-indoleacetic acid and kinetin partially restored the hemolysin-producing capacity in irradiated rabbits with respect to peak titer and the rate of rise. In accord with previous work, yeast was also completely restorative. Preparations of DNA and RNA enzymatically degraded in vitro by their specific nucleases were partially restorative, but the two polymerized nucleic acids, adenine, the nucleosides, and the nucleotides were not restorative. Croton oil used as a control for colchicine was without a significant restorative action. Colchicine and, to a lesser extent, yeast increased the hemolysin response in normal nonirradiated rabbits. None of the restorative agents significantly counteracted the lengthened induction period resulting from x radiation. 37 references. (auth)
- Research Organization:
- Univ. of Chicago; Argonne National Lab., Ill.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-007219
- OSTI ID:
- 4104478
- Journal Information:
- J. Infectious Diseases, Journal Name: J. Infectious Diseases Vol. Vol: 107
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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