ON INTERMEDIATE NUCLEOTIDE METABOLISM IN THE NORM AND RADIATION DISEASE (in Russian)
In the course of biochemical transformations of the elementary purine precursors, such as glycine, CO/sub 2/, and formic acid, there are formed, besides intermediary products of purine biosynthesis, also malic, glycolic, succinic, and fumaric acid as well as other by-products. It is confirmed that biosynthesis of the purine ring involves a stage of ribosidation of the purine precursors. The composition and metabolism of purine and pyrimidine compounds of bone marrow were studied. In the bone marrow there were detected adenylic, guanylic, inosinic, and uridilic acids, hypoxanthine, and uracil, as well as other low molecular purine and pyrimidine compounds. The content of these compounds greatly decreases in the bone marrow within the first days following x irradiation. Autolytic decomposition of RNA in the bone marrow increases directly after x irradiation but is greatly inhibited during the following days. A brief literature review is presented on intermediate nucleotide metabolism in the norm and in radiation disease. Disturbances of nucleotide metabolism, especially in autolitic splitting of nucleic acids, are considered as the primary and most essential metabolic disturbances caused by ionising radiations in the organism. (auth)
- Research Organization:
- Inst. of Biochemistry, Academy of Sciences, Moscow
- NSA Number:
- NSA-14-022741
- OSTI ID:
- 4154364
- Journal Information:
- Izvest. Akad. Nauk S.S.S.R., Ser. Biol., Journal Name: Izvest. Akad. Nauk S.S.S.R., Ser. Biol. Vol. Vol: No. 4
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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Related Subjects
ADENYLIC ACID
AMINO ACIDS
BIBLIOGRAPHY
BIOCHEMISTRY
BIOLOGY AND MEDICINE
BONE MARROW
CARBON DIOXIDE
CHEMICAL REACTIONS
DECOMPOSITION
DNA
FORMIC ACID
FUMARIC ACID
GLYCINE
GLYCOLIC ACID
GUANYLIC ACID
HETEROCYCLICS
HYPOXANTHINE
IRRADIATION
KETONES
MALIC ACID
METABOLISM
NUCLEIC ACIDS
ORGANIC ACIDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PURINES
PYRIMIDINES
RADIATION EFFECTS
RADIATION SICKNESS
REACTION KINETICS
RIBONUCLEIC ACID
STANDARDS
SUCCINIC ACID
URACILS
URIDYLIC ACID
X RADIATION