THE CONTENT OF FREE NUCLEOTIDES, NUCLEOSIDES, PURINE AND PYRIMIDINE BASES IN SOME TISSUES OF HEALTHY AND IRRADIATED RABBITS
Journal Article
·
· Biochemistry (U.S.S.R.) (English Translation)
OSTI ID:4195916
We have studied the content of nucleic acid fragments in rabbit tissues. In the liver, spleen, appendix, bone marrow, and mucosa of the small intestine we have found adenine, guanine, hypoxanthine, uracil, and the corresponding nucleosides and nucleotides, with the latter predominating in quantitative ratio. In blood, only adenylic acid is present in appreciable concentration. We have irradiated rabbits in doses of 1000 r and this causes changes in the quantitative (oaposition of these substances. In the liver, appendix, spleen, and bone marrow, the uridylic acid content increased and in a number of cases cytidylic acid, not present in the normal case, appeared. in the last two tissues the uridine content decreased. In the mucosa of the small intestine the uridylic acid content fell and the uridine content rose. Among the purine derivatives the greatest change was shown by inosine (it increased in liver and appendix, decreased in spleen), adenosine (rose in liver, fall in spleen and bone marrow), adenylic acid (increased in liver), and hypoxanthine (increased in liver, decreased in spleen). We have presented a possible mechanism for the change in nucleic acid fragments. (auth)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-14-009336
- OSTI ID:
- 4195916
- Journal Information:
- Biochemistry (U.S.S.R.) (English Translation), Journal Name: Biochemistry (U.S.S.R.) (English Translation) Vol. Vol: 24
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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Journal Article
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Tue Feb 28 23:00:00 EST 1961
· Biochemistry (U.S.S.R.) (English Translation)
·
OSTI ID:4039089
THE EFFECT OF PLUTONIUM ON THE CONTENT AND RENEWAL OF NUCLEIC ACIDS IN SOME RABBIT TISSUES
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·
Sat Oct 31 23:00:00 EST 1959
· Biochemistry (U.S.S.R.) (English Translation)
·
OSTI ID:4150314
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Journal Article
·
Wed Dec 31 23:00:00 EST 1958
· Biofizika (U.S.S.R.) For English translation see Biophysics (Engl. Transl.)
·
OSTI ID:4222336
Related Subjects
ADENINE
APPENDIX
BIOLOGY AND MEDICINE
BLOOD
BONE MARROW
CYTIDYLIC ACID
GUANINE
HETEROCYCLICS
HYPOXANTHINE
INOSINE
INTESTINE
KETONES
LIVER
METABOLISM
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC NITROGEN COMPOUNDS
PURINES
PYRIMIDINES
QUALITATIVE ANALYSIS
QUANTITY RATIO
RABBITS
RADIATION DOSES
RADIATION EFFECTS
SPLEEN
TISSUES
URACILS
APPENDIX
BIOLOGY AND MEDICINE
BLOOD
BONE MARROW
CYTIDYLIC ACID
GUANINE
HETEROCYCLICS
HYPOXANTHINE
INOSINE
INTESTINE
KETONES
LIVER
METABOLISM
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC NITROGEN COMPOUNDS
PURINES
PYRIMIDINES
QUALITATIVE ANALYSIS
QUANTITY RATIO
RABBITS
RADIATION DOSES
RADIATION EFFECTS
SPLEEN
TISSUES
URACILS