THE EFFECT OF PLUTONIUM ON THE CONTENT AND RENEWAL OF NUCLEIC ACIDS IN SOME RABBIT TISSUES
Results are reported from a study of the effect of Pu on the content of nucleic acids and the intensity of uptake of P/sup 32/ in these compounds in liver, bone marrow, and spleen of rabbits 1, 3, and 6 months after injection of the radioactive substance. When Pu was injected into rabbits in a dose of 7 mu curie/kg, there was a decrease in weight of the liver after 3 and 6 months and a fall in the number of cells in 1 g of bone marrow at all periods of the investigation. The maximum decrease in content of P-RNA in liver and spleen was observed 3 months after the injection. No change in bone marrow P-RNA was observed. The P-DNA content fell markedly in bone marrow and spleen after 3 months, and in liver after 6 months. The amount of DNA and RNA calculated on the weight of the liver fell more sharply than when calculated on the basis of unit weight of organ. The amount of P-DNA in all the organs after 3 and 6 months was 55 and 46%, and the amount of P-RNA was 56 and 36% of the corresponding results for the control animals. The specific activity of RNA increased 1.5 to 2 times in all the tissues in most of the periods of study. The greatest increase in DNA specific activity was in the liver. The activity of bone marrow depolymerases 6 months after injecting plutonium rose. The activity of DNA-aseII by 70%, of acid and alkaline RNA-ase increased by 96 and 240%, respectively. (auth)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-14-017717
- OSTI ID:
- 4150314
- Journal Information:
- Biochemistry (U.S.S.R.) (English Translation), Journal Name: Biochemistry (U.S.S.R.) (English Translation) Vol. Vol: 24
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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