THE EFFECT OF IONIZING RADIATION ON THE ACTIVITY OF BONE-MARROW NUCLEIC ACID DEPOLY-MERASES
Beginning with the work carried out under the direction of Hevesy it has become well known that iorizing radiation causes a great change in quantity and metabolism of the nucleic acids of man malian tissue. It showed in earlier studies that the amount of desoxyribonucleic acid (DNA) and ribonucleic acid (RNA) of bone marrow decreases sharply in the first hour after a single strong irradiation (dose 1000 r). It is difficult to explain this fall in amount of nucleic acids only by the inhibition of the synthesis of these compounds. It has been suggested that the observed fall in content of DNA and RNA is the result of the action of two opposing processes: a decrease in synthesis of the nucleic acids and an increase in their splitting. To test this idea the authors undertook to study nucleic acid depolymerase activity in bone marrow as the enzyme which first determines the splitting. (auth)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-14-012460
- OSTI ID:
- 4194604
- Journal Information:
- Biochemistry (U.S.S.R.) (English Translation), Journal Name: Biochemistry (U.S.S.R.) (English Translation) Vol. Vol: 24
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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