THE ACTION OF X-RAY RADIATION ON THE CONTENT OF NUCLEIC ACIDS IN CELL NUCLEI OF BONE MARROW (in Russian)
The content of nucleic acids (RNA and DNA) in separate young cells (myeloblasts) and mature cells (neutrophils) was determined in the unharmed cells of bone marrow taken from mice given a dose of 700 r. Treatment with cold (+ 1 ts C) 5% HClO/sub 4/ with contact times of 7, 15, and 40 min and for 6 and l5 min was used to separate various fractions of nucleic acid from the young cells (myeloblasts) and mature cells (neutrophils). Six hours after irradiation it was found that the fraction of RNA remained the same, but that the concentration of DNA decreased in both the myeloblasts and the neutrophils. Even if the organ from which the bone marrow was taken was shielded from the direct irradiation, the content of DNA was still found to be low. Those results point to the injury of certain general systems of the organism. A four-fold decrease in the amount of DNA in mycloblasts subject to direct irradiation may be the cause for the slow-down in mitotic activity and death of these cells. The relative stability of neutrophils to the action of radiation may be due to the smaller content of DNA in these cells and also to the fact that the neutrophils do not divide. (TTT)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-15-008543
- OSTI ID:
- 4096097
- Journal Information:
- Doklady Akad. Nauk, S.S.S.R., Journal Name: Doklady Akad. Nauk, S.S.S.R. Vol. Vol: 134
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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