THE EFFECT OF PROLONGED DAILY IRRADIATION OF NUCLEIC ACID TURNOVER IN SOME TISSUES OF THE RABBIT

Journal Article · Mon May 01 04:00:00 EDT 1961 · Biochemistry (U.S.S.R) (English Translation)

OSTI ID:4055051

Libinzon, R E; Konstantinova, V V

>The effect of prolonged irradiation with 30 r per day on the nucleic acids of rsbbits' liver and bone marrow was studied. The fractionation of the irradiation dose over a prolonged period was found to decrease the biological effect. In the liver the mean RNA and DNA phosphorus content per cell did hot vary appreciably; in the bone marrow a considerable fall in nucleic acid concentration was observed almost throughout the entire experimental period. The mean DNA-P content per cell was markedly increased both in-the liver and in bone marrow. In liver at cumulative doses of 420 and 2490 r, the rate of P/sup 3//sup 2/ incorporation into DNA wss increased 2.2 and 2.7 times, respectively. The specific activity (SA) of the DNA was definitely depressed at cumulative doses ranging from 900 to 1920 r. Changes in the SA of the RNA-P, although not so pronounced, were in the same direction as those in DNA. The specific activities of both the RNA-P and DNA-P in bone marrow were somewhat below control values at the 210 r dose level, and considerably elevated at dose levels 420, 630 and 2490 r. A theory was advanced about the mechanism of increased rates of DNA synthesis and the changes in mitotic activity following chronic irradiation. It is believed that such a reaction to chronic irradiation confers upon the cells an increased resistance to radiation. (auth)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-15-020562
• OSTI ID: 4055051
• Journal Information: Biochemistry (U.S.S.R) (English Translation), Journal Name: Biochemistry (U.S.S.R) (English Translation) Vol. Vol: 25
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
BONE MARROW
LIVER
METABOLISM
MITOSIS
NUCLEIC ACIDS
PHOSPHORUS
PHOSPHORUS 32
QUANTITY RATIO
RABBITS
RADIATION DOSES
RADIATION EFFECTS
RADIOSENSITIVITY
RIBONUCLEIC ACID
TISSUES