BONE MARROW REGENERATION IN IRRADIATED-BLED MICE STUDIED BY THYMIDINE-H$sup 3$
Journal Article
·
· Nuclear Hematology (England) Published in Nucl. Energy (Inst. Nucl. Eng.)
OSTI ID:4144548
Preliminary data concerning the effect of post-radiation bleeding anemia (erythropoietine) in organisms exposed to ionizing radiation are presented. The effect of bleeding, immediately after mice were sublethaly irradiated, on the proliferative activity of bone marrow cells was investigated. Bone marrow activity was estimated by incorporation of tritiated thymidine. The labeled compound enters DNA only in cells preparing for division. About 50% of bone marrow cells of normal, untreated mice are labeled. When mice were only irradiated, the level of incorporation varied, depending on the time at which observations were made after irradiation. In animals sacrificed after 24 hr, this value was low. On the 10th day, the number of labeled cells reached the same level as in untreated animals. But on the 15th day, incorporation again decreased. In bone marrow cells from mice irradiated and bled, the level of incorporation also varied with time. Twenty-four hours after treatment incoporation was low (9%). However, on the 10th day this value reached the same level as in untreated animals, and on the 15th day the same value was maintained. (M.C.G.)
- Research Organization:
- Inst. of Nuclear Sciences Boris Kidrich, Belgrade
- NSA Number:
- NSA-18-005071
- OSTI ID:
- 4144548
- Journal Information:
- Nuclear Hematology (England) Published in Nucl. Energy (Inst. Nucl. Eng.), Journal Name: Nuclear Hematology (England) Published in Nucl. Energy (Inst. Nucl. Eng.) Vol. Vol: 2; ISSN NUHEA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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