HISTOCHEMICAL INVESTIGATION OF THE BEHAVIOR OF SOME ENZYMES IN THE HEART MUSCLE AFTER WHOLE-BODY ROENTGEN IRRADIATION AS WELL AS AFTER LOCAL IRRADIATION OF THE HEART REGION (in German)
Journal Article
·
· Strahlentherapie (West Germany)
OSTI ID:4143058
The activity and distribution of several enzymes in heart muscle during different states of radiation sickness as well as after local irradiation of the heart were investigated histochemically. Guinea pigs received wholebody irradiation and local irradiations with 400 r each. Twenty-four hours after whole-body irradiation an increase and later on a decrease of DPNH-diaphorase and succinic acid dehydrogenase was observed. ATP-ase and alkaline phosphatase increased their activities during the first few days after irradiation; later on a decrease in activity was found. The activity of the acid phosphatase increased proportionally with the development of the radiation sickness. This effect might be due to degeneration events within the sarcoplasm. A decrease was observed for the non-specific esterases, while the activity of the E-600-resistant esterases increased. The results point out disturbances in heart muscle metabolism caused by radiation. This is proven by the decrease of enzymes which take part in the oxygen phosphorylizing events and in the active substrate transport from serum into the sarcoplasm. The histocheraical picture 4 days after local irradiation of the heart is similar to the one obtained 24 hr after whole-body irradiation. This is explained as due to a direct effect of x rays on the heart muscle. (auth)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-18-003554
- OSTI ID:
- 4143058
- Journal Information:
- Strahlentherapie (West Germany), Journal Name: Strahlentherapie (West Germany) Vol. Vol: 122; ISSN STRAA
- Country of Publication:
- Country unknown/Code not available
- Language:
- German
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