INVESTIGATION OF THE PATHOGENESIS OF RADIATION NEPHRITIS, CLINICAL AND EXPERIMENTAL. Period covered: July 1, 1959 to July 1, 1960 (Complete Report)

Technical Report · Fri Jul 01 04:00:00 EDT 1960

OSTI ID:4142636

Spargo, B H; Glagov, S

Enzyme histochemical methods were applied to the study of the x- irradiated rat kidney at severe dose levels and up to 227 days after irradiation. The earliest change noted was a modification in the manner of formazan precipitation in tubule cells. In addition to the fine uniform precipitate seen in the kidneys of control animals. the kidneys of irradiated animals showed accumulations of coarse formazan particles. These coarse granules appeared in tubule cells which seemed intact by standand staining methods and persisted in both apparently intact and atrophic tubules months after irradiation. There was a fairly well-defined comparative distribution of the coarse precipitation in the nephron. Only animals receiving 1000 r or more showed the coarse precipitate. In general, the changes in the hydrogen transfer and phosphatase systems paralleled the parenchymal loss and progressive renal fibrosis which characterized the postirradiation period. (auth)

• Research Organization: Chicago. Univ.
• NSA Number: NSA-14-025354
• OSTI ID: 4142636
• Report Number(s): TID-6477
• Country of Publication: United States
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
CYTOLOGY
ENZYMES
KIDNEYS
MICROSCOPY
RADIATION DOSES
RADIATION INJURIES
RATS
X RADIATION