TREATMENT OF VIRUSES
Patent
·
OSTI ID:4142521
A vaccine preparation method was developed for destroying the infectivity of live viruses while retaining the antigenicity. The method comprises exposing the virus to 0.5 to 6 x 10/sup 6/ rad of ionizing radiation (preferably gamma) in the presence of a protective agent. The protective agent is antioxidant in nature and should be used in amounts from 0.05to 0.3% (wt/vol). Histidine and sodium p-aminohippurate are preferred for influenza and mumps viruses respectively. The protective effects of various chemicals on the antigenicity of irradiated influenza A virus are illustrated. (D.L.C.)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-18-003583
- OSTI ID:
- 4142521
- Report Number(s):
- CA 660388
- Country of Publication:
- Canada
- Language:
- English
Similar Records
The Use of Gamma Radiation for the Preparation of Virus Vaccines
Factors influencing inactivation of infectivity and hemagglutinin of influenza virus by gamma radiation
Psoralen inactivation of influenza and herpes simplex viruses and of virus-infected cells
Journal Article
·
Wed Aug 01 00:00:00 EDT 1962
· Canadian Journal of Microbiology
·
OSTI ID:4776554
Factors influencing inactivation of infectivity and hemagglutinin of influenza virus by gamma radiation
Journal Article
·
Tue Aug 01 00:00:00 EDT 1961
· Canadian Journal of Microbiology
·
OSTI ID:4755788
Psoralen inactivation of influenza and herpes simplex viruses and of virus-infected cells
Journal Article
·
Mon Jun 01 00:00:00 EDT 1981
· Infect. Immun.; (United States)
·
OSTI ID:5576958