REGENERATION OF SERUM PROTEINS AFTER LOSS OF BLOOD IN IRRADIATED DOGS

Journal Article · Tue Jan 01 04:00:00 EST 1957 · Trudy Vsesoyuz. Konf. Med. Radiol.

OSTI ID:4131690

Rodionov, V M; Uspenskaya, V D; Zamyatkina, O G

Blood letting equivalent to 5 to 5.5% of the body weight was performed 1, 3. 6, and 45 days after irradiating dogs with a dose of 500 r, and Ringer's solution (1 1/2 to 2 times the volume of the blood removed) was injected into the femoral vein. The animals least able to survive a loss of blood were those subbected to blood letting six days after irradiation. The volume of circulating plasma determined by the dyestuff T-1824 exceeded the initial volume by 25% three days after the blood letting and decreased thereafter in the control group, but continued to rise slowly in the irradiated group until the death of the animal. I the unirradiated animals regeneration of the volume of blood took place by an increase in the number of erythrocytes with a decrease in plasma volume, while in the irradiated animals the number of erythrocytes continually decreased and the plasma volume remained the same or increased. I ths unirradiated group the blood albumin rose to 80% of its initial value after the lst day and then increased slowly until it reached the original value on the lOth day after blood letting. In the group subjected to radiation there was a rapid rise of blood albumin to 80% of the initial value, but then the blood albumin fell rapidly to 50 to 60% of the initial value at 10 to 15 days after the blood letting. The blood albumin remained constant at that value. The regeneration of plasma albumin is accomplished by two processes: First by a rapid mobilization of tissue albumin and second by a more gradual process wherein the body synthesizes albumins. In a normal dog the albumin fraction is 48 to 55% of the total plasma protein and the alpha globulins are 15 to 18% of the total. The alpha -globulin fraction rises to 25 to 30% of the total plasma protein in unirradiated dogs after blood letting, and it is 40 to 45% of the total plasma protein in irradiated dogs after blood letting. An increase in the alpha /sub 3/globulin content to 370% of its initial content was noted in some of the irradiated animals. There is a sbarp rise in the gamma -globulin content just

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-15-002554
• OSTI ID: 4131690
• Journal Information: Trudy Vsesoyuz. Konf. Med. Radiol., Journal Name: Trudy Vsesoyuz. Konf. Med. Radiol.
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

ALBUMINS
ANIMALS
BIOLOGY AND MEDICINE
BLOOD SERUM
DOGS
ERYTHROCYTES
HEMORRHAGE
METABOLISM
PROTEINS
RADIATION EFFECTS
REGENERATION
TISSUES