Experimental investigations on possibilities of chemical radiation protection

Journal Article · Mon Jan 01 04:00:00 EST 1973 · Wehrmed. Monatsschr., no. 11, pp. 337-341

OSTI ID:4130702

Ritter, K

The radioprotective effect of the sulph-hydryl compounds N-acetyl- homocysteine-thiolactone and cysteine in combination with fructose (Reducdyn(R)) at various high radiation doses, different doses of the protective chemical and varying times of application before and after irradiation was investigated in animal experiments. Altogether, 540 mice were subjected in groups to whole body irradiation with 500, 1,000 and 2,000 R, doses of 0.1, 0.25, 0.5 and 1.0 ml Reducdyn(R) being injected intraperitoneally at each dose. In the case of animals irradiated with 1,000 R these different dosages of the protective chemical were given immediately before and 6, 12, 24, and 48 hours before and after the irradiation. The results showed that the effect of the protective substance decreased with increasing radiation dose, and was directly dependent on the dosage of the substance. A significant radioprotective effect could be demonstrated both with the prophylactic use of Reducdyn(R) 48 hours before irradiation and also 24 hours after exposure. The utilisation of this type of chemical radioprotective substance is possible when exploding nuclear weapons or in accidents in nuclear engineering establishments. (orig.)

• Research Organization: Institut fuer Allgemeine und Experimentelle Pathologie der Bundeswehr, Mainz (F.R. Germany)
• NSA Number: NSA-33-009552
• OSTI ID: 4130702
• Journal Information: Wehrmed. Monatsschr., no. 11, pp. 337-341, Journal Name: Wehrmed. Monatsschr., no. 11, pp. 337-341
• Country of Publication: Germany
• Language: German

Related Subjects

*CYSTEINE-- RADIOSENSITIVITY EFFECTS
*FRUCTOSE-- RADIOSENSITIVITY EFFECTS
*LACTONES-- RADIOSENSITIVITY EFFECTS
560152* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Animals--Vertebrates
BIOLOGICAL RADIATION EFFECTS
INTRAPERITONEAL INJECTION
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
RADIATION DOSES
RADIOPROTECTIVE SUBSTANCES
WHOLE-BODY IRRADIATION
X RADIATION