THE EFFECT OF PSEUDOMONAS PYROGEN ON SURVIVAL OF IRRADIATED MICE
Survival of x-irradiated mice is under certain conditions increased by treatment with Pseudomonas pyrogen 24 hours before or 24 hours after irradiation. The extent of protection, estimated in two strains of mice by treatment 24 hours before irradiation, was influenced by the dose of pyrogen, the route of injection, the number of injections, and the endogenous bacterial flora of the experimental animals. Intravenous administration of 0.4 mu g decreased mortality in BUB mice, but 0.8 mu g was the minimal effective dose in CF. No. l/ Anl mice. At a dosage of 2 mu g, intravenous injection decreased mortality by more than 75% in both strains of mice; however, at this dosage, both intraperitoneal and subcutaneous injections were ineffectual. Multiple subcutaneous injections given for 5 days before irradiation failed to reduce mortality. Endogenous bacterial flora exent the most profound effect on radiation protection with PP, for no protection was observed in experiments in which Pseudomonas was the principle organism associated with terminal bacteremia during the first postirradiation week. (auth)
- Research Organization:
- Argonne National Lab., Ill.; Brown Univ., Providence
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-022173
- OSTI ID:
- 4044532
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Vol. Vol: 14
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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