THE EFFECT OF PROTEUS MORGANII ENDOTOXIN ON RADIATION MORTALITY IN MICE
A single 3- mu g injection of P. morganii endotoxin decreases radiation mortality in mice. The extent of reduction cf mortality and the range in time of effective treatmemt are functions of the radiation dose to which the animtals are exposed. Mortality was reduced at 600 r (LD/sub 71/(/sub 30/ if endotoxin was given between 48 hr before and 24 hr after irradidtion. The greatest reduction In mortity was observed if endotoxin was given 24 hr before irradiation; under these circumstances motality was reduced from 71 to 2%. Endotoxin injection after irradiation with 6OO r, or at an interval less than 24 hr before irradiation, was less effective than treatment 24 hr before irradiation. As the radiation dose increased to the supralethal levels of 700 and 750 r, a decrease was observed in both the extent of reduction of mortality and the range in time of effective treatment. Endotoxin 24 hr before 800 and 900 r did not decrease mortality, but an increased survival time was observed at 800 r. Endotoxin treatment resulted in an increased resistance to endogenous infection. Endotoxin treated mice sacrificed at intervals after irradiation with 700 r showed fewer infections than did controls. (auth)
- Research Organization:
- Brown Univ., Providence
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-001299
- OSTI ID:
- 4123194
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Vol. Vol: 13
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
Induction of generalized Shwartzman reaction (GSR) in irradiated rabbits by a single injection of endotoxin
CHANGES IN THE SENSITIVITY OF MICE TO TYPHOID ENDOTOXIN DURING RADIATION SICKNESS