Renal and adrenal factors in radiation-induced hypertension and nephrosclerosis

Thesis/Dissertation · Mon Jan 01 04:00:00 EST 1973

OSTI ID:4126232

Lurie, A G

Experiments were conducted in order to investigate the effects of adrenalectomy on the incidence, severity, and rate of progression of radiation- induced hypertension and nephrosclerosis in male rats. Adrenalectomized and non- adrenalectomized rats received either a single exposure of 500 R or 2000 R x radiation bilaterally to temporarily exteriorized kidneys, or a single exposure of 500 R to the whole body with shielding of temporarily exteriorized kidneys. Animals were sacrificed for study at 5 or 10 weeks following surgery and/or irradiation. The parameters which were evaluated included: systolic blood pressure; gross pathology; renal histopathology; food and fluid intake; urine output; urine and plasma potassium, sodium, and chloride concentrations; plasma corticosterone concentration; total body weight; and other organ weights (kidneys, spleen, heart, hypophysis, and adrenals). Additional studies were performed on selected rats to determine: the plasma renin and angiotensin activity; and the effects of adrenalectomy performed 3 months after bilateral renal irradiation on systolic blood pressure and renal histopathology. Hypertension and arteriolonephrosclerosis (ANS) were produced by all doses and all modes of irradiation in all adrenalectomized and non-adrenalectomized rats. (auth)

• Research Organization: Rochester Univ., N.Y. (USA). Dept. of Radiation Biology and Biophysics
• NSA Number: NSA-33-009540
• OSTI ID: 4126232
• Report Number(s): UR--3490-511
• Country of Publication: United States
• Language: English

Related Subjects

*ADRENALECTOMY-- RADIOSENSITIVITY EFFECTS
*HYPERTENSION-- RADIOINDUCTION
*NEPHROSCLEROSIS-- RADIOINDUCTION
560152* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Animals--Vertebrates
BIOLOGICAL RADIATION EFFECTS
BLOOD VESSELS
CARDIOVASCULAR DISEASES
EXTERNAL IRRADIATION
KIDNEYS
MALES
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
RADIATION DOSES
RATS
RESPONSE MODIFYING FACTORS
TIME DEPENDENCE
WHOLE-BODY IRRADIATION
X RADIATION