Effects of adrenalectomy, adrenal regeneration, and renal irradiation on blood pressure. [X rays; rats]

Journal Article · Wed Jan 31 23:00:00 EST 1979 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575143· OSTI ID:6311877

Rosenblum, M; Casarett, G W

Adrenalectomized, adrenal-enucleated and adrenal-intact rats were sham-irradiated or received an x-ray dose of 1100 rad bilaterally to temporarily exteriorized kidneys. Systolic blood pressures were measured at 10, 25, 40, 60, and 80 days after irradiation. At 100 days after irradiation the rats were sacrificed for gross pathologic examination and renal histopathologic studies of the kidneys. Adrenalectomy alone caused a significant drop in blood pressure which persisted throughout the experiment; adrenal regeneration in adrenal-enucleated rats or in those adrenalectomized rats in which adrenal tissue regenerated caused a significant increase in systolic blood pressure after 80 days postirradiation. Irradiation of adrenal-intact, adrenal-regenerating, or adrenalectomized rats did not cause significant elevation of blood pressure in comparison with that of the corresponding nonirradiated controls. Rats showing subtle renal histological changes usually showed somewhat higher blood pressures than rats showing no renal histological changes; a few rats which became severely hypertensive showed considerable histopathological changes in kidneys and other organs.

• Research Organization: Univ. of Rochester, NY
• OSTI ID: 6311877
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 77:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
ADRENAL HORMONES
ADRENALECTOMY
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REGENERATION
BLOOD PRESSURE
BODY
CARDIOVASCULAR DISEASES
CORTICOSTEROIDS
CORTICOSTERONE
DATA
DATA FORMS
DISEASES
ELECTROMAGNETIC RADIATION
ENDOCRINE GLANDS
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GLANDS
GLUCOCORTICOIDS
HORMONES
HYDROXY COMPOUNDS
HYPERTENSION
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
KETONES
KIDNEYS
LOCAL IRRADIATION
MAMMALS
MEDICINE
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PREGNANES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RATS
RECOVERY
RODENTS
STEROID HORMONES
STEROIDS
SURGERY
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES
X RADIATION