RELATION OF ADRENAL CORTICAL VOLUME TO SURVIVAL FOLLOWING X-IRRADIATION
Technical Report
·
OSTI ID:4137177
Adrenalectomized rats and rats containing regenerating enucleated adrenals or homotransplanted ad renals were irradiated with 600 r of x rays. The volumes of regenerated adrenal cortical tissue were measured at various times after enucleation and these volumes were correlated with the 30-day lethality of adrenal enucleated rats irradiated at the same time period. The mortality rate was inversely related to the volume of adrenal cortical tissue. There was no statistically significant difference between survival of control animals and of animals irradiated six days after enucleation. At this time the regenerated adrenals contained about 45% of the control volume of adrenal cortical tissue. Corticosterone measurements from adrenal vein plasma suggested that a regenerating adrenal is capable of near-normal secretion of this steroid by six days post-enucleation. The relationship of corticosterone to survival is not known. (auth)
- Research Organization:
- Rochester, N.Y. Univ. Atomic Energy Project
- NSA Number:
- NSA-14-025243
- OSTI ID:
- 4137177
- Report Number(s):
- UR-574
- Country of Publication:
- United States
- Language:
- English
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