Adrenal medullary regulation of rat renal cortical adrenergic receptors

Journal Article · Sun Nov 01 00:00:00 EST 1987 · American Journal of Physiology; (USA)

OSTI ID:7007375

Sundaresan, P R; Guarnaccia, M M; Izzo, Jr, J L ^[1]

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1. Univ. of Rochester Medical Center, NY (USA)

The role of the adrenal medulla in the regulation of renal cortical adrenergic receptors was investigated in renal cortical particular fractions from control rats and rats 6 wk after adrenal demedullation. The specific binding of ({sup 3}H)prazosin, ({sup 3}H)rauwolscine, and ({sup 125}I)iodocyanopindolol were used to quantitate {alpha}{sub 1}-, {alpha}{sub 2}-, and {beta}-adrenergic receptors, respectively. Adrenal demedullation increased the concentration of all three groups of renal adrenergic receptors; maximal number of binding sites (B{sub max}, per milligram membrane protein) for {alpha}{sub 1}-, and {alpha}{sub 2}-, and {beta}-adrenergic receptors were increased by 22, 18.5, and 25%, respectively. No differences were found in the equilibrium dissociation constants (K{sub D}) for any of the radioligands. Plasma corticosterone and plasma and renal norepinephrine levels were unchanged, whereas plasma epinephrine was decreased 72% by adrenal demedullation, renal cortical epinephrine was not detectable in control or demedullated animals. The results suggest that, in the physiological state, the adrenal medulla modulates the number of renal cortical adrenergic receptors, presumably through the actions of a circulating factor such as epinephrine.

• OSTI ID: 7007375
• Journal Information: American Journal of Physiology; (USA), Vol. 253:5; ISSN 0002-9513
• Country of Publication: United States
• Language: English

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