Hypertension after bilateral kidney irradiation in young and adult rats

Journal Article · Tue Sep 01 00:00:00 EDT 1987 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576933· OSTI ID:5846589

Jongejan, H T; van der Kogel, A J; Provoost, A P; Molenaar, J C

The mechanism of a rise in blood pressure after kidney irradiation is unclear but most likely of renal origin. We have investigated the role of the renin-angiotensin system and dietary salt restriction in the development of systolic hypertension after bilateral kidney irradiation in young and adult rats. Three to 12 months after a single X-ray dose of 7.5 or 12.5 Gy to both kidneys of young and adult rats, the systolic blood pressure (SBP) and plasma renin concentration (PRC) were measured regularly. A single X-ray dose of 12.5 Gy caused a moderate rise in SBP and a slight reduction in PRC in both young and adult rats. A dose of 7.5 Gy did not significantly alter the SBP or PRC during the follow-up period of 1 year. In a second experiment, the kidneys of young rats received an X-ray dose of 20 Gy. Subsequently, rats were kept on a standard diet (110 mmol sodium/kg) or a sodium-poor diet (10 mmol sodium/kg). On both diets, SBP started to rise rapidly 3 months after kidney irradiation. Sodium balance studies carried out at that time revealed an increased sodium retention in the irradiated rats compared to controls on the same diet. In rats on a low sodium intake, there was neither a delay nor an alleviation in the development of hypertension. Compared to controls, the PRC tended to be lower in irradiated rats up to 4 months after irradiation. Subsequently, malignant hypertension developed in all 20 Gy rats, resulting in pressure natriuresis, stimulating the renin-angiotensin system. Our findings indicated that hypertension after bilateral kidney irradiation was not primarily the result of an activation of the renin-angiotensin system. Although there were some indications that sodium retention played a role, dietary sodium restriction did not influence the development of hypertension.

• Research Organization: Erasmus Univ. Medical School, Rotterdam, The Netherlands
• OSTI ID: 5846589
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 111:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL COMPOUNDS
ANGIOTENSIN
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD PRESSURE
BODY
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CHLORIDES
CHLORINE COMPOUNDS
DISEASES
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
ENZYMES
GLOBULINS
HALIDES
HALOGEN COMPOUNDS
HYDROLASES
HYPERTENSION
IONIZING RADIATIONS
KIDNEYS
MAMMALS
NONSPECIFIC PEPTIDASES
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HYDROLASES
PROTEINS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RATS
RENIN
RODENTS
SODIUM CHLORIDES
SODIUM COMPOUNDS
SYMPTOMS
VASCULAR DISEASES
VASOCONSTRICTORS
VERTEBRATES
X RADIATION