Genetic Influence on the Renin-Angiotensin System: Evidence for a Renin Inhibitor in Hypertension-Prone Rats

Iwai, Junichi; Knudsen, Knud D.; Dahl, Lewis K.

doi:10.1084/jem.131.3.543

Genetic Influence on the Renin-Angiotensin System: Evidence for a Renin Inhibitor in Hypertension-Prone Rats

Journal Article · Sun Mar 01 00:00:00 EST 1970 · Journal of Experimental Medicine

DOI:https://doi.org/10.1084/jem.131.3.543· OSTI ID:1629169

Iwai, Junichi ^[1]; Knudsen, Knud D. ^[2]; Dahl, Lewis K. ^[2]

Brookhaven National Lab. (BNL), Upton, NY (United States); DOE/OSTI
Brookhaven National Lab. (BNL), Upton, NY (United States)

Two strains of rats with opposite genetic propensity for hypertension were tested for: (a) the sensitivity to injections of angiotensin and renin, and (b) the influence of their plasma on the reaction velocity of renin and its substrate in vitro. Intact hypertension-prone (S) rats on low salt had higher sensitivity to angiotensin and a lower sensitivity to renin than hypertension-resistant (R) rats. High NaCl diet did not change the response of the R rats to these injections, but increased the response to renin and angiotensin in intact S rats. Bilateral nephrectomy caused increased response to renin and a decreased response to angiotensin in the S rats, so that both strains were equivalent after bilateral nephrectomy. In vitro, plasma from intact S rats inhibited the activity of hog renin. Plasma from R rats showed no inhibition. Here, the inhibitor disappeared after bilateral nephrectomy. It was speculated that renin inhibitor may be involved in the development of hypertension by increasing sensitivity to angiotensin and other hypertensinogenic stimuli.

View Accepted Manuscript (DOE)

Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: SC0012704

OSTI ID:: 1629169

Journal Information:: Journal of Experimental Medicine, Journal Name: Journal of Experimental Medicine Journal Issue: 3 Vol. 131; ISSN 0022-1007

Publisher:: Rockefeller University PressCopyright Statement

Country of Publication:: United States

Language:: English

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Cited By (6)

The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease Kobori, Hiroyuki; Nangaku, Masaomi; Navar, L. Gabriel Pharmacological Reviews, Vol. 59, Issue 3 https://doi.org/10.1124/pr.59.3.3	journal	September 2007
Thick Ascending Limb Sodium Transport in the Pathogenesis of Hypertension Gonzalez-Vicente, Agustin; Saez, Fara; Monzon, Casandra M. Physiological Reviews, Vol. 99, Issue 1 https://doi.org/10.1152/physrev.00055.2017	journal	January 2019
Kidney, salt intake, and Na+,K(+)-ATPase inhibitors in hypertension. 1990 Corcoran Lecture. de Wardener, H. E. Hypertension, Vol. 17, Issue 6_pt_2 https://doi.org/10.1161/01.hyp.17.6.830	journal	June 1991
Dahl salt-susceptible and salt-resistant rats. A review. Rapp, J. P. Hypertension, Vol. 4, Issue 6 https://doi.org/10.1161/01.hyp.4.6.753	journal	November 1982
Genetic Influence on the Renin-Angiotensin System: LOW RENIN ACTIVITIES IN HYPERTENSION-PRONE RATS Iwai, Junichi; Dahl, Lewis K.; Knudsen, Knud D. Circulation Research, Vol. 32, Issue 6 https://doi.org/10.1161/01.res.32.6.678	journal	June 1973
A High Salt Diet Modulates the Gut Microbiota and Short Chain Fatty Acids Production in a Salt-Sensitive Hypertension Rat Model Bier, Ariel; Braun, Tzipi; Khasbab, Rawan Nutrients, Vol. 10, Issue 9 https://doi.org/10.3390/nu10091154	journal	August 2018

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