Genetic Influence on the Development of Renoprival Hypertension in Parabiotic Rats: Evidence that a Humoral Hypertensinogenic Factor is Produced in Kidney Tissue of Hypertension-Prone Rats

Journal Article · Mon Dec 01 00:00:00 EST 1969 · Journal of Experimental Medicine

DOI:https://doi.org/10.1084/jem.130.6.1353· OSTI ID:1629170

Knudsen, K. D. ^[1]; Iwai, J. ^[2]; Heine, M. ^[2]; Leitl, G. ^[2]; Dahl, L. K. ^[2]

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1. Brookhaven National Laboratory (BNL), Upton, NY (United States); DOE/OSTI
2. Brookhaven National Laboratory (BNL), Upton, NY (United States)

Rats from two strains with opposite constitutional predisposition to hypertension were joined in parabiosis and one partner was nephrectomized. The influence of genetic factors and of diet on the blood pressures of the two classes of parabionts, operated and intact, indicated that renoprival hypertension occurred with equal frequency in rats from both strains; that the development of renoprival hypertension depended on the influence from an intact S partner, or on a high salt intake, or on both. A nephrectomized S rat developing renoprival hypertension did not induce high blood pressure in its intact R partner. In this respect renoprival hypertension differs from salt and renal hypertension.The findings are interpreted to mean that the hypertensinogenic agent specific for S rats is produced by S kidneys.

• Research Organization: Brookhaven National Laboratory (BNL), Upton, NY (United States)
• Sponsoring Organization: Atomic Energy Commission; USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
• Grant/Contract Number: SC0012704
• OSTI ID: 1629170
• Journal Information: Journal of Experimental Medicine, Journal Name: Journal of Experimental Medicine Journal Issue: 6 Vol. 130; ISSN 0022-1007
• Publisher: Rockefeller University Press
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES