Rapid hypertensinogenic effect of lead: studies in the spontaneously hypertensive rat

Journal Article · Wed Jan 01 04:00:00 EST 1992 · Toxicology and Industrial Health; (United States)

DOI:https://doi.org/10.1177/074823379200800108· OSTI ID:5512630

Nakhoul, F; Kayne, L H; Brautbar, N; Hu, M S; McDonough, A; Eggena, P; Golub, M S; Berger, M; Chang, C T; Jamgotchian, N ^[1]

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1. Veterans Administration Medical Center, Sepulveda, CA (United States)

Chronic lead exposure may cause hypertension in normotensive rats. This hypertensinogenic effect has been attributed to perturbations in the renin-angiotensin axis, the contractile response of the vascular smooth muscle, or the intracellular Ca2+ homeostasis as a consequence of the inhibition of Na(+)-K(+)-ATPase activity. In this study we examined the short-term effect of lead exposure on blood pressure, plasma renin activity, vascular contractility, and renal Na(+)-K(+)-ATPase activity and abundance in the spontaneously hypertensive rat. Our data indicate that modest lead exposure caused blood pressure elevation within two weeks in this rat strain that is genetically susceptible to the development of hypertension. This rapid blood pressure-elevating effect did not appear to depend on the mechanisms described in hypertension associated with more chronic lead exposure listed above. This acute model provides an additional approach to the study of lead-induced hypertension.

• OSTI ID: 5512630
• Journal Information: Toxicology and Industrial Health; (United States), Journal Name: Toxicology and Industrial Health; (United States) Vol. 8:1-2; ISSN TIHEE; ISSN 0748-2337
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACID ANHYDRASES
ANIMALS
ATP-ASE
BLOOD PRESSURE
CARDIOVASCULAR DISEASES
CHRONIC EXPOSURE
DISEASES
ELEMENTS
ENVIRONMENTAL EXPOSURE
ENZYMES
HYDROLASES
HYPERTENSION
LEAD
MAMMALS
METALS
NONSPECIFIC PEPTIDASES
ORGANIC COMPOUNDS
PATHOGENESIS
PEPTIDE HYDROLASES
PHOSPHOHYDROLASES
PROTEINS
RATS
RENIN
RODENTS
SYMPTOMS
TOXICITY
VASCULAR DISEASES
VERTEBRATES