The role of vascular protein and renin in chronic two-kidney, one clip Goldblatt hypertension
Chronic hypertension was induced in rats by application of a clip for 17 or 20 weeks to the unilateral renal artery and leaving the contrarenal vessel intact. Some of the rats received antihypertensive treatment with phenoxybenzamine (POB). /sup 3/H-proline was injected into all rats in the 17th experimental week to observe the in vivo incorporation rates of /sup 3/H-proline into vascular non-collagenous protein and vascular collagen. Plasma renin activity (PRA) of decapitated rats was assayed in the terminal stage of the experiment. Significant differences were noted between 2K-1C hypertensive rats and sham-operated normotensive rats, the former rats having significantly higher incorporation rates of /sup 3/H-proline into non-collagenous protein and collagen of testicular or mesenteric artery. These results indicate that increased synthesis of vascular non-collagenous protein as well as collagen, especially of small arteries, plays a major role for the pathogenesis of chronic hypertension in 2K-1C rats, and renin does not contribute to elevation of the blood pressure in the maintenance phase of this type of experimental hypertension.
- Research Organization:
- Department of Urology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
- OSTI ID:
- 6816285
- Journal Information:
- Clin. Exp. Hypertens.; (United States), Vol. 4:3
- Country of Publication:
- United States
- Language:
- English
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COLLAGEN
BIOSYNTHESIS
HYPERTENSION
PATHOLOGY
PROTEINS
ARTERIES
BIOCHEMICAL REACTION KINETICS
BLOOD PRESSURE
COMPARATIVE EVALUATIONS
KIDNEYS
MYOCARDIUM
RATS
RENIN
TIME DEPENDENCE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMALS
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DISEASES
ENZYMES
HEART
HYDROLASES
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MUSCLES
NONSPECIFIC PEPTIDASES
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HYDROLASES
REACTION KINETICS
RODENTS
SCLEROPROTEINS
SYMPTOMS
SYNTHESIS
VASCULAR DISEASES
VERTEBRATES
550901* - Pathology- Tracer Techniques