STUDIES ON THE PATHOGENESIS OF NEPHROSCLEROSIS IN THE MOUSE FOLLOWING WHOLE- BODY X-RADIATION
Technical Report
·
OSTI ID:4123447
A progressive glomerular lesion is described in the LAF/sub 1/ mouse following sublethal whole-bcdy x irradiation (690 rad). The lesion is manifested by the proliferation of large, irregular pleomorphic cells in the intercapillary space and by the subsequent deposition of PAS positive material in these areds and in the glomerular basement membranes. The lesion first appears after a latent period of about 20 weeks and progresses rapidly from that time. It is suggested that simiInr but less severe lesions seen in nonirradiated aged LAF/sub 1/ mice may imply that the irradiation lesion is a manifestation of a "premature aging" phenomenon in the kidney although acceleration of what may be a spontaneous form of glomerulitis must be considered. (auth)
- Research Organization:
- Naval Radiological Defense Lab., San Francisco
- NSA Number:
- NSA-15-001243
- OSTI ID:
- 4123447
- Report Number(s):
- USNRDL-TR-455
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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