Progressive glomerulosclerosis and renal failure following perinatal gamma radiation in the beagle
The renal effects of whole body irradiation in the perinatal period were studied in the dog. Ninety-three dogs received a single sublethal exposure in the range of 270 to 435 R in either late gestation (55 days postcoitus) or early postnatal life (2 days postpartum) and were sacrificed at 70 days, 2, or 4 years of age. Early renal lesions in 70-day-old irradiated dogs were characterized by arrested glomerular maturation and degeneration resulting in reduced functional renal mass. Mature glomeruli exhibited mesangial proliferation. At 2 and 4 years of age, surviving irradiated dogs exhibited sever renal disease associated with progressive glomerular damage which was characterized by mesangial proliferation and compression of capillary lumina, epithelial degeneration and focal capsular adhesions, and ultimately obliterative glomerulosclerosis. Twenty-one of the 93 irradiated dogs died in renal failure before 4 years of age with advanced glomerulosclerosis. The phatogenesis of this progressive renal lesion may be related to the interaction of three specific factors. These include (1) the effect of direct radiation damage to mature kidney components; (2) the loss of outer cortical nephrons resulting in increased work load of the surviving nephrons; and (3) the effect of compensatory hypertrophy related to the loss of renal parenchyma as the rapid growth rates associated with kidney maturation.
- Research Organization:
- Colorado State Univ., Fort Collins
- OSTI ID:
- 6841844
- Journal Information:
- Lab. Invest.; (United States), Journal Name: Lab. Invest.; (United States) Vol. 42:6; ISSN LAINA
- Country of Publication:
- United States
- Language:
- English
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Characterization of renal damage following perinatal gamma radiation in the beagle
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEAGLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DOGS
ELECTROMAGNETIC RADIATION
ELECTRON MICROSCOPY
EXTERNAL IRRADIATION
GAMMA RADIATION
GLOMERULI
HYPERTROPHY
IONIZING RADIATIONS
IRRADIATION
KIDNEYS
MAMMALS
MICROSCOPY
ORGANS
PATHOLOGICAL CHANGES
PERINATAL IRRADIATION
PREGNANCY
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
VERTEBRATES
WHOLE-BODY IRRADIATION