Characterization of renal damage following perinatal gamma radiation in the beagle

Journal Article · Tue Nov 01 04:00:00 EST 1977 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574697· OSTI ID:5143591

Jaenke, R S; Phemister, R D; Angleton, G M; Davis, D D

Bilateral, whole-body /sup 60/Co ..gamma.. radiation (270 to 435 R) of beagles at 55 days in utero or 2 days of age resulted in a loss of kidney mass which was associated with thinning of the renal cortex and the presence of numerous immature glomeruli and nests of degenerating cells. Morphometric examination demonstrated a decrease in the density of mature and total glomeruli. These findings suggest that as a result of perinatal irradiation a significant reduction in structural and functional renal mass occurs which is due to a destruction of primitive metanephric tissue and an arrest in the further maturation of some nephrons. These events are associated with life-threatening secondary renal lesions which are characterized by progressive mesangial sclerosis of glomeruli and chronic renal failure.

• Research Organization: Colorado State Univ., Fort Collins
• OSTI ID: 5143591
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 72:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEAGLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DOGS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
IONIZING RADIATIONS
IRRADIATION
KIDNEYS
MAMMALS
NEONATES
ORGANS
PRENATAL IRRADIATION
RADIATION EFFECTS
RADIATIONS
VERTEBRATES