Perinatal radiation-induced renal damage in the beagle
- Colorado State Univ., Fort Collins (USA)
The developing perinatal kidney is particularly sensitive to radiation. The pathogenesis of the radiation-induced lesion is related to the destruction of outer cortical developing nephrons and direct radiation injury with secondary hemodynamic alterations in remnant nephrons. In this study, which is part of a life span investigation of the effects of whole-body gamma radiation during prenatal and early postnatal life, dogs were given 0, 0.16, 0.83, or 1.25 Gy irradiation at either 55 days postcoitus or 2 days postpartum and were examined morphometrically and histopathologically at 70 days of age. Although irradiated dogs showed no reduction in the total number of nephrons per kidney, there was a significant increase in the total number and relative percentage of immature, dysplastic glomeruli. In addition, deeper cortical glomeruli of irradiated kidneys exhibited mesangial sclerosis similar to that associated with progressive renal failure in our previous studies. These findings are in accord with those reported at doses of 2.24 to 3.57 Gy and demonstrate that the perinatal kidney is affected by radiation doses much lower than previously demonstrated.
- OSTI ID:
- 7006157
- Journal Information:
- Radiation Research; (USA), Journal Name: Radiation Research; (USA) Vol. 122:1; ISSN RAREA; ISSN 0033-7587
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BEAGLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DOGS
DOSES
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GAMMA RADIATION
IONIZING RADIATIONS
IRRADIATION
KIDNEYS
LIFE SPAN
MAMMALS
NEONATES
NERVE CELLS
ORGANS
PRENATAL EXPOSURE
PRENATAL IRRADIATION
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
SOMATIC CELLS
VERTEBRATES
WHOLE-BODY IRRADIATION