Partial-Body X-Ray Exposure and the Development of Progressive Intercapillary Glomerulosclerosis in the BALB/ c Mouse

Journal Article · Fri Feb 01 04:00:00 EST 1963 · Radiation Research

DOI:https://doi.org/10.2307/3571439· OSTI ID:4725796

Guttman, Paul H.; Kohn, Henry I.

BALB/c mice were subjected to whole- or partial-body x ray (250-kv) exposure at 58 to 93 days of age. After sacrifice about 500 days later, their kidneys were examined microscopically and were graded for intercapillary glomerulosclerosis (IGS), a naturally occurring aging process, accelerated by irradiation. The results lead to the conclusion that it is the absorbed dose of radiation in each kidney itself that determines the acceleration in the development of IGS in that organ. Finally, the high x ray dose (750 and 900 rads) which was possible under conditions of partial-body irradiation resulted in more severe glomerular lesions than previously observed and in the appearance of early renal arteriosclerosis in association with the most advanced degrees of IGS.

• Research Organization: Univ. of California, San Francisco
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-023163
• OSTI ID: 4725796
• Journal Information: Radiation Research, Journal Name: Radiation Research Journal Issue: 2 Vol. 18; ISSN 0033-7587
• Publisher: Radiation Research Society
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ABSORPTION
AGE
BIOLOGY AND MEDICINE
BLOOD VESSELS
KIDNEYS
MICE
MICROSCOPY
PHYSIOLOGY
QUANTITY RATIO
RADIATION DOSES
RADIATION INJURIES
X RADIATION