A STUDY OF THE KIDNEY IN THE LAF$sub 1$ MOUSE AFTER CONTINUED DAILY GAMMA- IRRADIATION, WITH PARTICULAR REFERENCE TO PROGRESSIVE INTERCAPILLARY GLOMERULOSCLEROSIS

Journal Article · Sun Oct 01 04:00:00 EDT 1961 · Intern. J. Radiation Biol.

OSTI ID:4803516

Guttman, P H; Kohn, H I; Lesher, S

Beginning at 100 days of age, LAF/sub 1/ mice were exposed to 12 or 14 r per day of Co/sup 60/ gamma -rays. In the unirradiated animals, the degree of intercapillary glomerulosclerosis was relatively constant from 100 to 500 days of age, after which it progressively increased. The animals receiving 24 r per day did not survive beyond 500 days of age; their kidneys were like those of the unirradiated animals. In animals receiving 12 r per day, the degree of intercapillary glomerulosclerosis after 300 days of age was only a little greater than in the unirradiated animals, though consistently so. This was true even in 700-day-old animals that had received an accumulated dose of 6600 r. The small renal arteries and arterioles were not altered. Thus continued small daily doses of gamma -radiation resulted in much less renal damage than had been found in a previous study with single doses of x rays. (auth)

• Research Organization: Univ. of California School of Medicine, San Francisco
• NSA Number: NSA-16-012899
• OSTI ID: 4803516
• Journal Information: Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 4
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
BIOLOGY AND MEDICINE
BLOOD VESSELS
COBALT 60
GAMMA RADIATION
KIDNEYS
LIFETIME
MICE
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
X RADIATION