THE RECOVERY OF LETHALLY IRRADIATED DOGS GIVEN INFUSIONS OF AUTOLOGOUS LEUKOCYTES PRESERVED AT-80C
Journal Article
·
· Blood (U.S.)
OSTI ID:4112231
Nine normal mongrel dogs were exposed to 1200 r wholebody irradiation at 4 to 5 r/min. They were then given intravenous infusions of 2.12 to 20 x 10/sup 9/ autologous leukocytes that had been previously stored at -80 deg C in 10% dimethylsulfoxide. Three dogs survived with delayed but complete hematopoietic recovery. Three showed beginning marrow regeneration but died within 3 to 4 weeks of irradiation. Three given less than 6 x 10/sup 9/ cells died within 21 days. The number of leukocytes infused was critical since there was no survivor among the dogs receiving less than 9 x 10/sup 9/ cells. It is concluded that peripheral blood contains primitive cells capable of repopulating marrow spaces and restoring marrow function. (auth)
- Research Organization:
- Mary Imogene Bassett Hospital, Cooperstown, N.Y.
- NSA Number:
- NSA-18-006681
- OSTI ID:
- 4112231
- Journal Information:
- Blood (U.S.), Journal Name: Blood (U.S.) Vol. Vol: 23; ISSN BLOOA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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