MODIFICATION OF X-RADIATION LETHALITY BY AUTOLOGOUS MARROW INFUSION IN DOGS
Dogs have been treated, after x-irradiation with doses of 400 r and 600 r, by injection of either homologous or autologous bone marrow. The bone marrow was obtained by pre-irradiation biopsy and was reinjected either into the animal from which it was drawn (autologous) or into an alternate recipient (homologous). Injection of 2 x 10/sup 9/ autologous nucleated cells successfully protectcd all dogs given either 400 r or 600 r. Dogs given 1 x 10 /sup 9/ autologous nucleated cells after 600 r failed to survive. No protection was provided by injection of 2 x 10/sup 9/ homologous nucleated cells after 400 r nor by injection of 2 x 10/ sup 9/ or 5 x 10/sup 9/ homologous nucleated cells after 600 r. It is proposed that a different:al species sensitivity to foreign cell implants accounts for the failure of homologous marrow infusions is dogs in contradistinction to the protection provided by homologous or heterologous marrow implants in rats and mice, and by homologous implants in monkeys. (auth)
- Research Organization:
- Naval Radiological Defense Lab., San Francisco
- NSA Number:
- NSA-12-007682
- OSTI ID:
- 4352988
- Report Number(s):
- USNRDL-TR-207
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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